RESUMO
Liver cirrhosis is a disease related to numerous severe complications such as portal hypertension or collateral circulation. Varices that are located outside the gastroesophageal region (ectopic varices) such as the anorectal region, colon, ileum or gallbladder are unusual. In many cases, they are related to the existence of portal vein thrombosis. We report the case of a patient with a severe hemorrhage of gallbladder varices due to alcohol-related cirrhosis.
Assuntos
Vesícula Biliar/irrigação sanguínea , Hemorragia/etiologia , Cirrose Hepática/complicações , Varizes/complicações , Evolução Fatal , Vesícula Biliar/diagnóstico por imagem , Hemoperitônio/diagnóstico por imagem , Hemoperitônio/terapia , Hemorragia/diagnóstico por imagem , Humanos , Cirrose Hepática/diagnóstico por imagem , Masculino , Pessoa de Meia-Idade , Varizes/diagnóstico por imagemAssuntos
Equinococose Hepática/complicações , Hipertensão Portal/etiologia , Antagonistas Adrenérgicos beta/uso terapêutico , Adulto , Albendazol/uso terapêutico , Anti-Helmínticos/uso terapêutico , Angiografia por Tomografia Computadorizada , Equinococose Hepática/diagnóstico por imagem , Equinococose Hepática/cirurgia , Procedimentos Cirúrgicos Eletivos , Varizes Esofágicas e Gástricas/etiologia , Hemorragia Gastrointestinal/etiologia , Hepatectomia , Humanos , Imageamento por Ressonância Magnética , Masculino , RecidivaRESUMO
BACKGROUND/AIMS: The objective of our study was to determine the epidemiological, laboratory, and serological characteristics of patients with chronic hepatitis B virus (HBV) infection and normal transaminases. The study also aimed to evaluate liver damage by measuring the liver fibrosis (LF) grade and to identify possible factors associated with the presence of fibrosis. METHODS: A retrospective observational study was conducted in patients with chronic HBV infection and classified as inactive carriers or immune-tolerant. Epidemiological variables of age, sex, immigrant, alcohol consumption, and body mass index (BMI), as well as virological variables (HBV DNA) and transaminase level were collected throughout the follow-up. The LF grade was evaluated by transient elastography. The cutoff value for significant fibrosis (SF) was liver stiffness ≥7.9 kPa. RESULTS: A total of 214 patients were included in the analysis, and 62% of them had a BMI ≥25 kg/m². During follow-up, 4% of patients showed transaminase elevation ( < 1.5 times normal). Most patients had a viral DNA level < 2,000 IU/mL (83%). Data on LF were available in 160 patients; of these, 14% had SF, 9% F3, and 6% F4. The variables associated with the presence of SF were transaminase alteration during follow-up, as 23% of patients with SF had elevated transaminases versus 3% of patients without SF (P < 0.005), and BMI, as the vast majority of patients with SF (88%) had a BMI ≥25 kg/m² versus 56% of patients without SF (P < 0.05). CONCLUSIONS: In patients with chronic HBV infection and normal transaminases, liver damage does not seem to be related to DNA levels, alcohol consumption, or immigrant status. SF seems to be associated with transaminase alteration during follow-up and elevated BMI. It is therefore recommended to measure LF grade with validated non-invasive methods in such patients.
Assuntos
Humanos , Consumo de Bebidas Alcoólicas , Índice de Massa Corporal , DNA , DNA Viral , Técnicas de Imagem por Elasticidade , Emigrantes e Imigrantes , Fibrose , Seguimentos , Antígenos E da Hepatite B , Hepatite B Crônica , Hepatite Crônica , Cirrose Hepática , Fígado , Estudo Observacional , Estudos Retrospectivos , TransaminasesRESUMO
No disponible
Assuntos
Humanos , Feminino , Idoso de 80 Anos ou mais , Histiocitose de Células de Langerhans/diagnóstico , Neoplasias do Colo/diagnóstico , Dor Abdominal/etiologia , Colonoscopia , Diagnóstico DiferencialRESUMO
No disponible
